Turkey tail has the most substantial clinical literature of any functional mushroom — and also the widest gap between what…
Reishi is the mushroom people reach for at night, and it is worth being clear about what that does and…
These two get compared constantly, usually as if you have to pick one. You do not — they are aimed…
Two different fungi share the name cordyceps, and they are not interchangeable. One grows on caterpillars at high altitude and…
Powder is the cheapest, capsules are the easiest, extracts are the most concentrated. That summary is true and almost useless…
If you learn one thing before buying a mushroom supplement, make it this one. The difference between a fruiting-body product…
Lion’s mane has one of the cleaner safety records among supplements sold for cognition — it has been eaten as…
Nobody takes lion’s mane for a week. The research that reported anything useful ran for a month or more —…
The honest answer to “how much lion’s mane should I take” is that it depends on what is in the…
Hericium ist der Pilz, zu dem Menschen greifen, wenn sie klarer denken wollen. Er wird als Nootropikum verkauft, als Gedächtnisstütze,…
Lion’s mane is the mushroom people reach for when they want to think more clearly. It is sold as a…
We don't invent effects. Below are 17 papers from PubMed (National Library of Medicine, USA) covering every mushroom in our range. Each link opens the original study record.
Cognition, NGF, mood
Mori K. et al. · Phytotherapy Research · 2009
In 30 participants aged 50–80, 16 weeks of Lion's Mane powder significantly raised cognitive scale scores versus placebo; the effect declined 4 weeks after they stopped taking it.
PubMed PMID: 18844328Saitsu Y. et al. · Biomedical Research · 2019
Twelve weeks of extract intake was accompanied by improved Benton test and MMSE scores in healthy adults.
PubMed PMID: 31413233Nagano M. et al. · Biomedical Research · 2010
Among women eating Lion's Mane cookies, scores for anxiety, irritation and concentration difficulty went down.
PubMed PMID: 20834180Mori K. et al. · Biological & Pharmaceutical Bulletin · 2008
Mechanistic work: hericenones raised NGF mRNA expression and protein secretion in cell culture in a dose-dependent way.
PubMed PMID: 18758067
Endurance, oxygen metabolism, immunity
Chen S. et al. · Journal of Alternative and Complementary Medicine · 2010
In healthy older participants, 12 weeks of Cs-4 raised the metabolic and ventilatory thresholds compared with placebo.
PubMed PMID: 20804368Hirsch K.R. et al. · Journal of Dietary Supplements · 2017
Three weeks of a C. militaris-based mushroom blend improved VO₂max and time to exhaustion under high-intensity load.
PubMed PMID: 27408987Das G. et al. · Frontiers in Pharmacology · 2020
Systematic review of cordycepin and cordyceps polysaccharides: modulation of macrophages, NK cells and the cytokine response.
PubMed PMID: 33628175
Sleep, stress, fatigue, safety
Tang W. et al. · Journal of Medicinal Food · 2005
132 patients: 8 weeks of the extract significantly reduced the sense of fatigue and improved wellbeing relative to placebo.
PubMed PMID: 15857210Zhao H. et al. · Evid. Based Complement. Altern. Med. · 2012
In patients on endocrine therapy, 4 weeks of intake improved fatigue, anxiety and quality-of-life scores (FACT-F).
PubMed PMID: 22203880Wachtel-Galor S. et al. · British Journal of Nutrition · 2004
A safety study: 10 days of intake did not alter liver function, kidney function or DNA damage markers, while plasma antioxidant status rose.
PubMed PMID: 14756912Jin X. et al. · Cochrane Database of Systematic Reviews · 2016
Review of 5 RCTs: reishi is not recommended as a first-line therapy on its own, but showed an effect on immune response as an adjunct.
PubMed PMID: 27045603
Immune response, PSK and PSP polysaccharides
Torkelson C.J. et al. · ISRN Oncology · 2012
Dose-escalation study after radiotherapy: intake was well tolerated and a dose-dependent recovery of immune cell populations was observed.
PubMed PMID: 22701186Eliza W.L. et al. · Recent Pat. Inflamm. Allergy Drug Discov. · 2012
Meta-analysis of 13 RCTs (over 9,000 patients): turkey tail preparations added to standard therapy were associated with lower 5-year mortality.
PubMed PMID: 22185453Study Group of Immunochemotherapy with PSK · The Lancet · 1994
The classic multicentre RCT: adding polysaccharide K to chemotherapy improved 5-year disease-free survival.
PubMed PMID: 7910230
Antioxidants, oxidative stress, polysaccharides
Najafzadeh M. et al. · BioFactors · 2007
In lymphocytes from IBD patients, chaga extract reduced oxidative DNA damage by roughly 54% in an ex vivo experiment.
PubMed PMID: 18997282Glamočlija J. et al. · Journal of Ethnopharmacology · 2015
Comparison of samples from different regions: phenolic acid profile, antioxidant and antimicrobial activity all depend on where the raw material came from.
PubMed PMID: 25576897Szychowski K.A. et al. · Journal of Traditional and Complementary Medicine · 2021
Review of composition (betulin, inotodiol, beta-glucans) and the current state of the evidence, including the limits of existing data.
PubMed PMID: 34195023This information is provided for reference, to give scientific context. It does not describe the effects of any Herbalson product. Herbalson products are dietary supplements. They are not medicines and are not intended to diagnose, treat, cure or prevent any disease. Consult a healthcare professional before use.
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